Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Evoked potential abnormalities in myotonic dystrophy.

D S Thompson, J B Woodward, S P Ringel

    Electroencephalography and Clinical Neurophysiology
    |November 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Collective leadership in collaborative practice: a qualitative secondary analysis of how plural leadership is enacted in practice.

    Journal of interprofessional care·2025
    Same author

    Investigating properties of sweet cherry (Prunus avium) flower buds that help promote freezing avoidance by supercooling.

    Plant biology (Stuttgart, Germany)·2024
    Same author

    Sexual function, quality of life, and fertility in women who had surgery for neonatal Hirschsprung's disease.

    The British journal of surgery·2021
    Same author

    Development and validation of the Axillary Sweating Daily Diary: a patient-reported outcome measure to assess axillary sweating severity.

    Journal of patient-reported outcomes·2019
    Same author

    Micro-spectrometer for fusion plasma boundary measurements.

    The Review of scientific instruments·2018
    Same author

    Obstetric interventions and maternal morbidity among women who experience severe postpartum hemorrhage during cesarean delivery.

    International journal of obstetric anesthesia·2017

    Brain stem auditory evoked potentials (BAEPs) reveal significant central nervous system involvement in myotonic dystrophy (MYD), particularly in males. These findings provide neurophysiological evidence of brain stem pathology in MYD patients.

    Area of Science:

    • Neuroscience
    • Neurology
    • Genetics

    Background:

    • Myotonic dystrophy (MYD) is a multisystem disorder.
    • Previous studies suggest central nervous system (CNS) involvement in MYD, evidenced by EEG abnormalities and cognitive impairments.
    • Brain stem auditory evoked potentials (BAEPs) and median nerve somatosensory evoked potentials (MSSEPs) have not been previously reported in MYD.

    Purpose of the Study:

    • To investigate brain stem auditory evoked potentials (BAEPs) and median nerve somatosensory evoked potentials (MSSEPs) in patients with myotonic dystrophy (MYD).
    • To provide neurophysiological evidence of central nervous system (CNS) involvement, specifically brain stem pathology, in MYD.

    Main Methods:

    • Evaluated 15 patients with myotonic dystrophy (MYD) using BAEPs and MSSEPs.

    Related Experiment Videos

  • Analyzed interwave latencies for BAEPs (wave I-III, III-V) and thalamic complex (P15-N19) for MSSEPs.
  • Assessed correlations between evoked potential abnormalities, patient age, sex, and clinical findings.

    • Main Results:

    • Abnormal BAEPs were observed in 53.3% of MYD patients (P < 0.05), indicating brain stem dysfunction (pons and midbrain).
    • Abnormal MSSEPs (13.3%) showed thalamic complex delays, despite normal clinical sensory exams and peripheral nerve conduction.
    • A significant sex difference was noted: 8/9 males had abnormal evoked potentials, versus 0/6 females.

    Conclusions:

    • Abnormal BAEPs provide strong neurophysiological evidence for brain stem pathology in myotonic dystrophy (MYD).
    • While MSSEP findings were not statistically significant, they suggest potential thalamic involvement.
    • The higher incidence of abnormalities in males warrants further investigation into sex-related differences in MYD neuropathology.