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Plasmacytoid T-cell clusters in non-specific lymphadenitis.
Virchows Archiv. B, Cell Pathology Including Molecular Pathology
|January 1, 1983
Summary
Clusters of plasmacytoid T-cells (PTC) were found in nonspecific lymphadenitis. These cells, potentially transformed T-lymphocytes, may play a role in immune responses.
Area of Science:
- Immunology
- Pathology
- Cell Biology
Background:
- Nonspecific lymphadenitis involves lymph node inflammation.
- The cellular composition of lymphadenitis is complex and not fully understood.
Purpose of the Study:
- To investigate the occurrence and morphology of lymphoblast clusters in nonspecific lymphadenitis.
- To characterize the nature and potential origin of these cell clusters.
Main Methods:
- Analysis of 500 unselected cases of nonspecific lymphadenitis.
- Morphological examination of lymph node tissues.
- Interpretation based on recent immunologic findings.
Main Results:
- Sixty-eight cases exhibited clusters of uniform, medium-sized cells, identified as plasmacytoid T-cells (PTC).
- PTC were typically located near venules, not in T-nodules or B-regions.
- PTC showed features of end cells, with necrotic cells phagocytosed by macrophages, sometimes creating a starry sky pattern.
Conclusions:
- Plasmacytoid T-cells (PTC) are present in nonspecific lymphadenitis.
- PTC may arise from T-lymphocyte transformation and represent end cells.
- The exact function of PTC remains unknown but may involve lymphokine secretion.