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Psoriasis therapy: a current perspective.

The Western Journal of Medicine

|August 1, 1983

Summary

This summary is machine-generated.

Psoriasis treatments range from topical steroids and coal tars to phototherapy and systemic methotrexate for severe cases. New psoralen UV therapy is effective, but long-term safety is unknown, and retinoids are experimental.

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Area of Science:

Dermatology
Immunology

Background:

Psoriasis is a prevalent papulosquamous skin condition posing significant therapeutic challenges.
Effective management requires a spectrum of treatment modalities tailored to disease severity.

Purpose of the Study:

To review current and emerging therapeutic strategies for managing psoriasis.
To highlight the efficacy and limitations of various treatment options.

Main Methods:

Review of established and novel psoriasis treatments.
Discussion of topical therapies, phototherapy, systemic agents, and experimental drugs.

Main Results:

Topical steroids, coal tars, and anthralin offer effective treatment for many patients.
Phototherapy, including psoralen plus ultraviolet A (PUVA), shows efficacy but requires further safety evaluation.

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Systemic methotrexate is indicated for severe cutaneous and arthropathic psoriasis.

Synthetic retinoids are under investigation for severe disease forms.

Conclusions:

A multi-modal approach is essential for effective psoriasis management.
Ongoing research is crucial for refining existing treatments and developing new therapies with improved safety profiles.