[Morphological studies of the effect of substance P partial sequences on nerve tissue culture]

Explants of the telencephalon and of the ganglion trigeminale from chick embryos were cultivated in the presence of 10(-7) M of substance P partial sequences SP 1-2 (Arg-Pro . 22HCl) and SP3-4 (Lys(Z)-Pro . HCl or Lys-Pro . 2HBr). The morphology of the living outgrowth in fact the growth of nerve fibers, cell migration and proliferation was observed. SP1-2 and SP3-4 influenced particularly the morphology of pns cultures.