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Nerve changes in morphea.

T Kobayasi, J Serup

    Acta Dermato-Venereologica
    |January 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Morphea affects peripheral nerves with myxedematous changes and fibrosis in the nerve sheath. Lymphocytes, plasma cells, mast cells, and myofibroblasts infiltrate these nerves, causing minor axon and Schwann cell degeneration.

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    Area of Science:

    • Dermatology
    • Neuropathology

    Background:

    • Morphea is a connective tissue disease affecting the skin.
    • Peripheral nerve involvement in morphea is not well understood.

    Purpose of the Study:

    • To investigate ultrastructural changes in peripheral nerves within morphea lesions.

    Main Methods:

    • Analysis of 39 peripheral nerves from 12 morphea patients.
    • Examination of mesenchymal nerve components (epi-, peri-, endoneurium) via electron microscopy.

    Main Results:

    • Observed myxedematous changes, collagen degradation, and abnormal fibrosis in nerve sheaths.
    • Identified infiltration by lymphocytes, plasma cells, mast cells, and myofibroblasts.
    • Suggestive evidence for perineural cells as a source of myofibroblasts.

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  • Noted slight degeneration in axons and Schwann cells.

    • Conclusions:

    • Morphea induces significant ultrastructural alterations in peripheral nerves.
    • Inflammatory and fibrotic processes characterize nerve involvement in morphea.
    • Further research into the role of myofibroblasts and perineural cells is warranted.