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Zinc in multiple sclerosis.

P Dore-Duffy, F Catalanotto, J O Donaldson

    Annals of Neurology
    |October 1, 1983
    PubMed
    Summary
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    Zinc levels are altered in multiple sclerosis (MS) patients. Specifically, erythrocyte-bound zinc is increased, suggesting changes in zinc regulation in MS.

    Area of Science:

    • Neuroscience
    • Biochemistry
    • Clinical Chemistry

    Background:

    • Zinc is an essential trace element involved in numerous biological processes.
    • Alterations in zinc homeostasis have been implicated in various neurological disorders.
    • Understanding zinc profiles in multiple sclerosis (MS) may offer insights into disease mechanisms.

    Purpose of the Study:

    • To investigate and compare zinc levels in patients with multiple sclerosis (MS), healthy controls, and patients with other neurological diseases.
    • To analyze different fractions of zinc, including plasma, albumin-bound, protein-bound, alpha 2 macroglobulin-bound, and erythrocyte-bound zinc.

    Main Methods:

    • Blood samples were collected from 68 MS patients, 62 normal volunteers, and 13 patients with other neurological diseases.

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  • Plasma zinc, albumin-bound zinc, protein-bound zinc, alpha 2 macroglobulin-bound zinc, and erythrocyte-bound zinc levels were measured.
  • Statistical analysis was performed to compare zinc levels between the groups.

    • Main Results:

    • Plasma zinc was slightly increased in MS patients and significantly increased in patients with other neurological impairments compared to controls.
    • Albumin-bound and protein-bound zinc levels were normal across all groups.
    • Alpha 2 macroglobulin-bound zinc was significantly lower in MS patients than in controls.
    • Erythrocyte-bound zinc levels were significantly increased in MS patients but normal in patients with other neurological impairments.

    Conclusions:

    • Elevated erythrocyte-bound zinc in MS patients, independent of dietary intake, suggests dysregulation of zinc compartmentalization mechanisms.
    • Specific alterations in zinc fractions, particularly decreased alpha 2 macroglobulin-bound zinc and increased erythrocyte-bound zinc, characterize multiple sclerosis.
    • Further research into zinc metabolism in MS may reveal potential therapeutic targets.