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[Results of psychomotor development in hypothyroidism detected at birth]
Insights
Congenital hypothyroidism in children, detected at birth, generally shows normal psychomotor development with some temporary language and posture delays. Early global development at 6 months correlates with epiphyseal plate development, indicating potential long-term neurological impacts.
Area of Science:
- Pediatric Endocrinology
- Developmental Neuroscience
- Clinical Genetics
Context:
- Congenital hypothyroidism (CH) affects psychomotor development.
- Early detection and management are crucial for neurodevelopmental outcomes.
- Longitudinal studies on CH psychomotor development are essential.
Purpose:
- To assess the psychomotor development of 35 children with congenital hypothyroidism.
- To correlate developmental quotients with clinical factors and epiphyseal development.
- To identify potential long-term neurological impairments in CH patients.
Summary:
- Thirty-five children with congenital hypothyroidism (CH) were followed for psychomotor development.
- Global IQ quotients remained normal across ages 6 months to 5 years.
- Transient delays in posture and language were observed, with full recovery by age 4.
- A correlation was found between 6-month global development and epiphyseal surface area.
- Neurological evaluation revealed impairments in posture, coordination, and fine motor skills.
Impact:
- Provides insights into the neurodevelopmental trajectory of children with CH.
- Highlights the importance of early diagnosis and monitoring for CH.
- Suggests potential benefits of interventions targeting posture, coordination, and fine motor skills in CH management.
Abstract:
Thirty-five children in whom hypothyroidism was detected at birth were studied with respect to psychomotor development. A 5 year-follow-up was obtained in a few cases. The I.Q. was established using Brunet-Lezine's test or Griffith's test after age 30 months. Global quotients where normal: 98 + 10 at 6 months, 96 + 7 at 1 year, 99 + 7 at 3 years, 97 + 7 at 4 years and 97 + 4 at 5 years. Partial development quotients were normal concerning coordination and sociability. A transitory decrease was found at 1 year concerning posture and at 2 and 3 years concerning language, both returning to normal by age 4. These results were correlated with several factors: there was no significant difference between athyroidism and ectopia at the different ages but a difference appeared for partial development quotients at 2 and 3 years. There was no correlation between development quotients, clinical scores and dates of diagnosis. On the contrary, a significant correlation was found global development quotients at 6 months and the surfaces of epiphyses. Finally, a precise neurological evaluation showed an impairment of posture, coordination and fine movements of the extremities.