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Related Experiment Videos

Evidence that natural selection acts on silent mutation.

M Conrad, C Friedlander, M Goodman

    Bio Systems
    |January 1, 1983
    PubMed
    Summary

    Strong codon biases in mammalian hemoglobin, yeast cytochrome c, and human interferon suggest indirect selection on silent mutations. This supports the bootstrapping hypothesis where mutations hitchhike with facilitated traits, not simple gene expression maximization.

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    Corrigendum to "European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)" [Redox Biol. 13 (2017) 94-162].

    Redox biology·2017

    Area of Science:

    • Molecular Biology
    • Evolutionary Genetics
    • Bioinformatics

    Background:

    • Nucleic acid sequences exhibit codon usage biases.
    • The evolutionary pressures driving these biases are not fully understood.

    Purpose of the Study:

    • To investigate the evolutionary forces shaping codon usage bias in specific genes.
    • To test hypotheses regarding selection on silent mutations and gene expression.

    Main Methods:

    • Analysis of mammalian hemoglobin, yeast cytochrome c, and human interferon nucleic acid sequence data.
    • Statistical examination of codon frequencies and their evolutionary stability.

    Main Results:

    • Identified significant codon usage biases across the studied genes.
    • Observed that these biases are evolutionarily persistent.
    • Data are consistent with the bootstrapping hypothesis for evolutionary rate modulation.

    Conclusions:

    • Indirect selection likely influences silent mutations.
    • Codon usage bias may facilitate the appearance of advantageous traits through hitchhiking.
    • Simple maximization of gene expression is unlikely to be the sole driver of observed biases.

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