Batrachotoxin induced axonal necrosis followed by regeneration

Batrachotoxin (BTX), when applied to peripheral nerve in concentrations sufficient to block impulse transmission and axonal transport, causes axonal necrosis. Quantitation of this phenomenon reveals reduction of both myelinated and unmyelinated fibers 7 days post-BTX injection. Evidence for regeneration correlates with the previously reported recovery of postsynaptic events.