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[Human transfer factor. II. Clinical results with the large pool transfer factor]
Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1983
Summary
Large pool therapeutic (TF) is effective for immunological diseases, particularly immunodeficiencies. Repeated TF administrations are necessary for sustained therapeutic benefits, functioning as a substitution therapy with good compatibility.
Area of Science:
- Immunology
- Transfusion Medicine
Context:
- Investigating the efficacy of large pool therapeutic (TF) in patients with immunological disorders.
- TF derived from pooled buffy-coats of fresh stored whole blood administered to 21 patients.
Purpose:
- To evaluate the clinical and immunological effectiveness of large pool TF in patients with diseases of immunological origin.
- To assess the safety and long-term effects of TF therapy.
Summary:
- Large pool TF demonstrated clinical effectiveness in 9/18 patients and immunological effectiveness in 16/18 patients.
- TF therapy showed greater efficacy in immunodeficiencies compared to autoimmune diseases.
- Treatment requires repeated administration, acting as a substitution therapy with good compatibility and no observed side-effects.
Impact:
- Highlights the complexity of immunological diseases beyond in vitro correlates.
- Suggests TF therapy as a viable option for immunological disorders, warranting further controlled trials.
- Provides a foundation for investigating controversial therapeutic findings in autoimmune diseases and tumors.