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Related Experiment Videos

A possible new HLA-DR allele.

H Betuel, L Gebuhrer, J Lambert

    Human Immunology
    |November 1, 1983
    PubMed
    Summary

    Serum 901, containing anti-HLA antibodies, identified a specific human leukocyte antigen (HLA) haplotype in European Caucasoid individuals. This discovery aids in understanding HLA diversity and potential transplant compatibility.

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    Area of Science:

    • Immunogenetics
    • Human Leukocyte Antigen (HLA) system
    • Serology

    Background:

    • Routine screening of anti-HLA DR reagents is crucial for antibody identification.
    • Serum 901 was derived from a Black woman post-delivery and contained polyspecific HLA A and B antibodies.

    Purpose of the Study:

    • To characterize the specificity of antibodies in serum 901.
    • To investigate the prevalence and segregation of the recognized HLA haplotype in a Caucasoid population.

    Main Methods:

    • Platelet absorption of serum 901.
    • Testing against a panel of European Caucasoid donors typed for HLA-DR and HLA-MT antigens.
    • Reactions with homozygous typing cells (HTC) for HLA-DW.
    • Segregation analysis in 18 informative Caucasoid families.

    Main Results:

    • Serum 901 reacted with B cells of 8.4% of the panel donors, identifying a specific HLA haplotype.
    • The antibody showed negative reactions with HLA-DW1 to DW8 HTC.
    • Family studies confirmed the segregation of the recognized haplotype, with homozygous individuals identified as HTC DW9.

    Conclusions:

    • Serum 901 defines a specific HLA haplotype, likely a novel or rare one, within the Caucasoid population.
    • The findings contribute to the understanding of HLA polymorphism and can aid in HLA typing and antibody identification for transplantation.

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