Arachidonic acid and other free fatty acid changes during abortion induced by prostaglandin F2alpha

Serum free fatty acids (FFA's) were measured after intra-amniotic injection of prostaglandin F2alpha (PGF2alpha) for the induction of abortion in eight healthy women in the midtrimester of pregnancy. The total FFA levels increased in all cases during the period between PGF2alpha administration and abortion. This lipolysis most likely is secondary to the effect of the catecholamines as indicated by the temporal relationship between increased plasma and urine catecholamine and serum FFA levels. The percentage of arachidonic acid in the total amount of FFA's decreased after administration of PGF2alpha. This proportional decrease in arachidonic acid (p less than 0.05) may be due to selective utilization for the production of endogenous prostaglandins.