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[Severe anaphylactoid accidents occurring during general anesthesia].

G Occelli, Y Saban, A Barbarin

    Annales Francaises D'Anesthesie Et De Reanimation
    |January 1, 1983
    PubMed
    Summary

    Anaphylactoid reactions during anesthesia were linked to specific drugs like suxamethonium. Allergy history and histamine release tests helped identify causative agents, despite normal immunoglobulin levels.

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    Area of Science:

    • Anesthesiology
    • Immunology
    • Allergy

    Background:

    • Anaphylactoid reactions during general anesthesia pose significant clinical challenges.
    • Understanding the mechanisms and identifying causative agents is crucial for patient safety.

    Observation:

    • Four patients experiencing anaphylactoid events during anesthesia were studied.
    • Clinical signs, basophil degranulation, and serum histamine levels were assessed.
    • Previous allergies were noted in all patients, though standard immunoglobulin (IgE, C3, C4) and complement (CH50) levels were normal.

    Findings:

    • Positive skin tests identified specific anesthetic drugs as causative agents in all cases.
    • Identified drugs included suxamethonium, fluid gelatin (Plasmion), and droperidol.

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  • Discrepancies were observed between in vitro and in vivo basophil degranulation tests.

    • Implications:

    • This study highlights the importance of thorough allergy assessment in patients undergoing anesthesia.
    • Skin testing is a valuable tool for identifying drug-induced anaphylactoid reactions.
    • Further investigation into drug-specific hypersensitivity mechanisms during anesthesia is warranted.