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A Primary Neuron Culture System for the Study of Herpes Simplex Virus Latency and Reactivation
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Isolation of a herpesvirus from a bald eagle nestling

D E Docherty, R I Romaine, R L Knight

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    |October 1, 1983
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    Herpes

    Herpes simplex type 1 (HSV‑1) is a widespread pathogen responsible for orolabial lesions. It is an enveloped, double-stranded DNA (dsDNA) virus belonging to the family Herpesviridae. Once the virus infects a host cell, its double‑stranded DNA genome is delivered into the nucleus, where a coordinated cascade of immediate‑early, early, and late gene expression directs viral DNA replication, structural protein synthesis, and virion assembly. After primary infection of epithelial cells, HSV-1...