Indomethacin v. dexamethasone in the suppression of corneal neovascularization

A 7-0 silk suture was placed in one of the corneas of each of 18 albino rabbits as a vasogenic stimulus. Two drops of normal saline, a 10.3 mg/ml suspension of indomethacin or a 0.1% suspension of dexamethasone, allocated in double-masked fashion, were then instilled in the 18 eyes three times per day. There was a statistically significant difference (p less than 0.01) in the rate of neovascularization between the 6 control corneas and the 12 treated corneas but no significant difference in the rate or the quality of neovascularization between the 6 indomethacin-treated corneas and the 6 dexamethasone-treated corneas.