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Related Experiment Videos

[Cefotaxime concentration in the prostatic tissue].

K Fujita, H M Fujita, K Fujii

    The Japanese Journal of Antibiotics
    |June 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

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    Cefotaxime (CTX) achieves high concentrations in rat prostatic tissue for over two hours after injection. Human prostatic tissue also shows significant CTX activity following intravenous administration.

    Area of Science:

    • Pharmacokinetics and drug distribution studies.
    • Comparative analysis of cefotaxime levels in biological tissues.

    Context:

    • Evaluating the efficacy of antibiotics in treating prostate infections.
    • Understanding cefotaxime penetration into the prostate gland.

    Purpose:

    • To determine cefotaxime concentrations in serum and prostatic tissue in rats and humans.
    • To assess the duration and level of cefotaxime in prostatic tissue.

    Summary:

    • In rats, cefotaxime (CTX) maintained high levels (40-100 µg/g) in prostatic tissue for at least 2 hours after a 100 mg/kg intraperitoneal dose.
    • Human patients receiving 1g of CTX intravenously exhibited prostatic tissue concentrations of 6.8 ± 4.1 µg/g.

    Impact:

    • Provides crucial data for optimizing cefotaxime dosing regimens for prostatitis treatment.

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  • Highlights the potential of cefotaxime in achieving therapeutic concentrations within the prostate.