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Related Experiment Videos

Epilepsy presenting as infantile autism? Two case studies.

C Gillberg, H Schaumann

    Neuropediatrics
    |November 1, 1983
    PubMed
    Summary

    Two cases of infantile autism showed late-emerging EEG abnormalities. Anticonvulsive treatment resolved both psychotic symptoms and EEG changes, suggesting a link between epilepsy and autism.

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    Area of Science:

    • Neuroscience
    • Child Psychiatry
    • Clinical Neurology

    Background:

    • Infantile autism is a complex neurodevelopmental disorder.
    • Epileptiform EEG abnormalities can be associated with autism spectrum disorder.
    • The relationship between EEG changes and psychotic symptoms in autism requires further investigation.

    Observation:

    • Two cases of infantile autism presented with initially undetected epileptogenic EEG changes.
    • These EEG abnormalities became apparent later in the clinical course of the disorder.
    • Psychotic symptoms were a prominent feature in both cases.

    Findings:

    • Anticonvulsive pharmacological treatment was administered.
    • This treatment resulted in the complete resolution of psychotic symptoms.
    • Simultaneously, pathological EEG changes also disappeared following treatment.

    Implications:

    • The findings suggest a potential link between epileptogenic activity and psychotic manifestations in infantile autism.
    • Anticonvulsive therapy may offer a novel therapeutic approach for specific autism-related symptoms.
    • Further research is warranted to explore the underlying mechanisms connecting epilepsy, EEG changes, and autism.

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