Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Alpha 1-antitrypsin, alpha 2-macroglobulin and complement C4 in human benign prostatic hyperplasia.

M van Sande, K Van Camp

    Urological Research
    |January 1, 1983
    PubMed
    Summary

    Benign prostatic hyperplasia tissue contains high levels of alpha 1-antitrypsin. Anti-androgen treatment affects alpha 2-macroglobulin but not complement C4 levels in the prostate.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Efficient mRNA electroporation of peripheral blood mononuclear cells to detect memory T cell responses for immunomonitoring purposes.

    Journal of immunological methods·2010
    Same author

    Parent information binder: individualizing education for parents of preterm infants.

    Neonatal network : NN·1996
    Same author

    Transurethral microwave thermotherapy in the treatment of chronic abacterial prostatitis: a 2 years follow-up.

    Acta urologica Belgica·1995
    Same author

    [Sterilization and the mentally handicapped: who decides?].

    Verhandelingen - Koninklijke Academie voor Geneeskunde van Belgie·1993
    Same author

    A simple and economical strategy for downstream processing of specific antibodies to human transferrin from egg yolk.

    Journal of immunological methods·1992
    Same author

    Distribution of proline-specific aminopeptidases in human tissues and body fluids.

    European journal of clinical chemistry and clinical biochemistry : journal of the Forum of European Clinical Chemistry Societies·1992

    Area of Science:

    • Urology
    • Biochemistry
    • Immunology

    Background:

    • Benign prostatic hyperplasia (BPH) is a common condition in aging men.
    • Globulin concentrations in prostate tissue are not well understood.
    • Understanding these concentrations may reveal insights into BPH pathogenesis.

    Purpose of the Study:

    • To quantify alpha 1-antitrypsin, alpha 2-macroglobulin, and complement C4 in BPH tissue.
    • To investigate the impact of anti-androgen therapy on these globulin levels.

    Main Methods:

    • Tissue samples from BPH patients were analyzed.
    • Radial immunodiffusion was used to measure globulin concentrations.
    • Patients were grouped based on prior anti-androgen treatment.

    Related Experiment Videos

    Main Results:

    • Alpha 1-antitrypsin was found in high concentrations within prostate tissue.
    • Anti-androgen treatment significantly altered alpha 2-macroglobulin levels across prostatic lobes.
    • Complement C4 concentrations remained unaffected by the treatment.

    Conclusions:

    • Prostate tissue exhibits substantial alpha 1-antitrypsin levels.
    • Anti-androgens modulate alpha 2-macroglobulin in BPH, suggesting a potential role in disease progression.
    • Complement C4 appears independent of anti-androgen therapy in this context.