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Equine marker genes: polymorphism for plasminogen.

L R Weitkamp, P Costello-Leary, S A Guttormsen

Animal Blood Groups and Biochemical Genetics

|January 1, 1983

Summary

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Equine plasminogen (PLG) exhibits autosomal polymorphism with two alleles, PLG1 and PLG2. Allele frequencies varied across horse breeds, with no linkage found to other genetic markers.

Area of Science:

Genetics
Veterinary Science
Biochemistry

Background:

Plasminogen is a key protein in the fibrinolytic system.
Genetic variations in plasminogen can influence physiological processes.
Understanding equine plasminogen polymorphism is important for breed genetics.

Purpose of the Study:

To investigate the genetic polymorphism of equine plasminogen (PLG).
To determine the frequencies of PLG alleles in different horse breeds.
To assess the linkage of PLG with other genetic markers.

Main Methods:

Plasma samples were analyzed using isoelectric focusing.
Immunofixation with a goat anti-human plasminogen antibody identified alleles.
Allele frequencies were calculated in Standardbreds, Thoroughbreds, and Shetland ponies.

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Linkage analysis was performed with 13 marker loci.

Main Results:

Two autosomal alleles, PLG1 and PLG2, were identified in equine plasma.
The frequency of the PLG2 allele was 0.16 in Standardbreds, 0.20 in Thoroughbreds, and 0.39 in Shetland ponies.
No evidence of linkage between PLG and the 13 marker loci was found.

Conclusions:

Equine plasminogen exhibits genetic polymorphism.
Allele frequencies differ significantly among horse breeds.
The PLG gene is likely located on a different chromosome than the 13 marker loci studied.