Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists01:27

Chemotherapy-Induced Nausea and Vomiting: 5-HT3 Receptor Antagonists

927
5-HT3 receptor antagonists, such as dolasetron, granisetron (Kytril), ondansetron (Zofran), and palonosetron (Axoli), are crucial in managing chemotherapy-induced nausea and vomiting (CINV) and postoperative nausea. These drugs selectively block 5-HT3 receptors in the visceral vagal and spinal afferent nerves, chemoreceptor trigger zone, and the vomiting center. They have a rapid onset of action and can be given as a single dose before chemotherapy. Ondansetron and granisetron, in particular,...
927

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Observation of the diphoton decay of the Higgs boson and measurement of its properties.

The European physical journal. C, Particles and fields·2015
Same author

Search for displaced supersymmetry in events with an electron and a muon with large impact parameters.

Physical review letters·2015
Same author

Study of vector boson scattering and search for new physics in events with two same-sign leptons and two jets.

Physical review letters·2015
Same author

Measurement of prompt ψ(2S) to J/ψ yield ratios in Pb-Pb and p-p collisions at sqrt[sNN]=2.76  TeV.

Physical review letters·2015
Same author

Excision of a giant anterior chest wall neurofibroma and chest wall reconstruction with methlymethacrylate and vertical rectus abdominis musculocutaneous flap: case report.

Nigerian journal of medicine : journal of the National Association of Resident Doctors of Nigeria·2014
Same author

A novel use of an anterior cruciate ligament FlipCutter® in intramedullary nailing to minimise soft tissue damage.

Annals of the Royal College of Surgeons of England·2014

Related Experiment Video

Updated: May 1, 2026

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
07:47

Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

Published on: December 13, 2015

8.4K

High-dose cisplatin in hypertonic saline.

R F Ozols, B J Corden, J Jacob

    Annals of Internal Medicine
    |January 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    High-dose cisplatin chemotherapy effectively treats advanced testicular cancer with an 88% response rate. This high-dose regimen showed no significant negative impact on kidney function in patients with poor prognosis nonseminomatous testicular cancer.

    More Related Videos

    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
    04:04

    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

    Published on: February 12, 2017

    9.2K
    Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
    09:52

    Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

    Published on: March 16, 2018

    8.8K

    Related Experiment Videos

    Last Updated: May 1, 2026

    Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance
    07:47

    Custom-designed Laser-based Heating Apparatus for Triggered Release of Cisplatin from Thermosensitive Liposomes with Magnetic Resonance Image Guidance

    Published on: December 13, 2015

    8.4K
    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer
    04:04

    Endobronchial Ultrasound-guided Intratumoral Injection of Cisplatin for the Treatment of Isolated Mediastinal Recurrence of Lung Cancer

    Published on: February 12, 2017

    9.2K
    Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity
    09:52

    Trans-Tympanic Drug Delivery for the Treatment of Ototoxicity

    Published on: March 16, 2018

    8.8K

    Area of Science:

    • Oncology
    • Nephrology
    • Pharmacology

    Background:

    • Cisplatin is a crucial chemotherapy agent but its use is limited by dose-limiting toxicities, particularly nephrotoxicity.
    • High-dose cisplatin regimens are being explored to improve efficacy in aggressive cancers.
    • Managing cisplatin-induced toxicities, especially renal, is vital for patient outcomes.

    Purpose of the Study:

    • To evaluate the safety and efficacy of high-dose cisplatin in patients with poor-prognosis nonseminomatous testicular cancer.
    • To assess the impact of high-dose cisplatin on renal function.
    • To investigate the response rates in ovarian cancer patients with relapsed disease.

    Main Methods:

    • Administered high-dose cisplatin (200 mg/m2) with extensive hydration and supportive care.
    • Treated 17 patients with advanced nonseminomatous testicular cancer and 6 patients with relapsed ovarian cancer.
    • Monitored renal function through creatinine clearance and serum creatinine levels.

    Main Results:

    • Achieved an 88% complete response rate in testicular cancer patients with advanced bulky disease.
    • Observed no statistically significant decrease in creatinine clearance or elevation of serum creatinine in testicular cancer patients.
    • Obtained three partial responses in six ovarian cancer patients with relapsed disease.
    • Two ovarian cancer patients experienced transient serum creatinine elevations (4-5 mg/dL).
    • Hypertonic saline did not mitigate nonrenal toxicities.

    Conclusions:

    • High-dose cisplatin, combined with chemotherapy and aggressive hydration, is effective and shows acceptable renal safety in poor-prognosis testicular cancer.
    • This regimen offers a promising treatment option for high-risk testicular cancer patients.
    • Further investigation is warranted for ovarian cancer patients, as responses were observed but toxicity needs careful management.