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[Ct-morphology and exocrine function in chronic pancreatitis].

P Malfertheiner, W Maier, A Walliser

    Zeitschrift Fur Gastroenterologie
    |December 1, 1983
    PubMed
    Summary

    Computer-tomography (CT) effectively correlates with exocrine pancreatic function in chronic pancreatitis patients. Severe functional impairment strongly links to CT findings like calcifications and duct ectasia.

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    Interdigestive cycling in chronic pancreatitis: altered coordination among pancreatic secretion, motility, and hormones.

    Gastroenterology·1995

    Area of Science:

    • Gastroenterology
    • Radiology
    • Medical Imaging

    Background:

    • Chronic pancreatitis (CP) diagnosis relies on clinical, functional, and morphological assessments.
    • Exocrine pancreatic function testing provides crucial data but can be invasive.
    • Computerized tomography (CT) offers detailed morphological insights into pancreatic changes.

    Purpose of the Study:

    • To quantitatively correlate computer-tomographic (CT) findings with exocrine pancreatic function in patients with chronic pancreatitis.
    • To determine the sensitivity of CT in detecting CP across different stages of functional impairment.

    Main Methods:

    • A quantitative correlation study involving 48 patients diagnosed with chronic pancreatitis.
    • Exocrine pancreatic function was assessed following secretin-ceruletide stimulation.
    • Morphological changes were evaluated using computer-tomography (CT).

    Main Results:

    • A significant correlation (r = 0.7841, p < 0.001) was observed between the degree of morphological changes on CT and the stage of functional impairment.
    • Bicarbonate secretion per hour demonstrated the strongest correlation with CT findings (r = -0.7193, p < 0.001).
    • CT sensitivity was limited (50%) in detecting CP with slight functional impairment (Stage 1).

    Conclusions:

    • CT findings correlate significantly with exocrine pancreatic function in chronic pancreatitis.
    • Specific CT signs like calcifications and pancreatic duct ectasia are associated with severe functional impairment.
    • CT may have limited sensitivity for early-stage chronic pancreatitis with mild functional deficits.

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