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Bitemporal lesions dissociate auditory evoked potentials and perception.

D L Woods, R T Knight, H J Neville

    Electroencephalography and Clinical Neurophysiology
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

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    Sudden deafness in a stroke patient revealed that auditory evoked potentials (AEPs) can be normal even without sound perception. This suggests auditory cortex lesions can disconnect hearing ability from neural responses.

    Area of Science:

    • Neuroscience
    • Auditory Neuroscience
    • Clinical Neurology

    Background:

    • Investigating auditory evoked potentials (AEPs) in patients with cortical deafness.
    • Understanding the relationship between auditory perception and neural processing after stroke.

    Observation:

    • An 82-year-old female patient experienced sudden deafness post-stroke, with normal brain-stem auditory evoked potentials (BAEPs) but elevated pure tone thresholds.
    • Bilateral superior temporal plane lesions, including auditory cortex, were identified via CT scans.
    • Auditory stimuli, perceived or not, elicited normal P1, N1, and P2 AEP components, with similar refractory properties to controls.

    Findings:

    • Dissociation between auditory perception and long-latency AEPs (P1, N1, P2) in a patient with bilateral auditory cortex lesions.

    Related Experiment Videos

  • Neural circuits for N1-P2 generation appear adjacent to, but distinct from, those critical for auditory perception.
  • Normal AEP scalp topography despite profound hearing loss.

    • Implications:

    • Bilateral auditory cortex damage can lead to cortical deafness while preserving basic auditory pathway function.
    • AEPs may not fully reflect conscious auditory perception in cases of specific cortical lesions.
    • Further research into the neural substrates of auditory perception and AEP generation is warranted.