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[Diphenoxylate poisoning].

E Villalobos Cuevas, F Soto Oviedo, C Arnaiz Toledo

    Boletin Medico Del Hospital Infantil De Mexico
    |January 1, 1978
    PubMed
    Summary

    Lomotil overdose in young children is often accidental. Early stomach washing and naloxone chloride treatment rapidly reversed symptoms with no adverse effects.

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    Area of Science:

    • Pediatric Emergency Medicine
    • Clinical Toxicology

    Background:

    • Lomotil (diphenoxylate/atropine) overdose is a significant concern in pediatric populations.
    • Accidental ingestions frequently lead to emergency room admissions.

    Purpose of the Study:

    • To analyze the clinical presentation and treatment outcomes of Lomotil intoxication in pediatric patients.
    • To evaluate the efficacy and safety of naloxone chloride as an antidote.

    Main Methods:

    • Retrospective review of 18 pediatric patients admitted with Lomotil intoxication in 1976.
    • Assessment of initial symptoms, treatment interventions (gastric lavage, naloxone), and patient outcomes.

    Main Results:

    • The majority of intoxications (88.8%) were accidental, with patients aged 4 months to 3 years.
    • Atropinism and diphenoxylate toxicity presented equally; 22% had mixed symptoms.
    • Naloxone chloride administration resulted in rapid symptom improvement within 15 seconds with no observed side-effects.
    • Earlier gastric lavage correlated with reduced symptom severity.

    Conclusions:

    • Lomotil intoxication is a notable cause of pediatric emergency visits.
    • Naloxone chloride is a highly effective and safe antidote for Lomotil overdose in children.
    • Prompt medical intervention, including gastric lavage and naloxone, is crucial for managing Lomotil toxicity.

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