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Related Experiment Videos

Renal cell carcinoma--angioinfarction.

W K Mebust, J W Weigel, K R Lee

    The Journal of Urology
    |February 1, 1984
    PubMed
    Summary

    Angioinfarction for renal cell carcinoma showed a 4% mortality rate and significant side effects. While it reduced tumor volume, it did not improve survival rates compared to other treatments.

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    Area of Science:

    • Urology
    • Oncology
    • Interventional Radiology

    Background:

    • Renal cell carcinoma (RCC) poses significant treatment challenges.
    • Angioinfarction is an interventional radiology technique used for tumor ablation.

    Purpose of the Study:

    • To evaluate the efficacy and complications of angioinfarction in patients with renal cell carcinoma.
    • To assess the impact of angioinfarction on tumor volume, survival, and treatment outcomes.

    Main Methods:

    • Retrospective analysis of 46 patients undergoing angioinfarction for renal cell carcinoma.
    • Evaluation of complications, tumor volume changes, and survival rates.
    • Comparison with other treatment modalities like delayed nephrectomy, chemotherapy, and immune ribonucleic acid (RNA) therapy.

    Main Results:

    • Mortality rate was 4%; common complications included fever, ileus, and leukocytosis (86-90%).
    • Absolute ethanol as a medium caused significant organ damage.
    • Angioinfarction with absorbable gelatin sponge and Gianturco coils reduced tumor volume by 30% in 75% of patients.
    • No significant reduction in metastatic tumor burden, operative time, or blood loss was observed.
    • Adjuvant immune RNA therapy showed a potential survival benefit in metastatic cases, but numbers were insufficient for definitive conclusions.
    • No significant survival advantage was found for infarction with delayed nephrectomy and medroxyprogesterone acetate compared to palliative nephrectomy or chemotherapy.

    Conclusions:

    • Angioinfarction can reduce renal cell carcinoma tumor volume but is associated with substantial morbidity.
    • Current evidence does not support improved survival with angioinfarction compared to established treatments.
    • Further research is needed to clarify the role of adjuvant therapies and refine angioinfarction techniques.
    • Macrophage maturation assay may aid in clinical follow-up.

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