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Related Experiment Videos

Essential requirement for major histocompatibility complex recognition in T-cell tolerance induction.

J R Lamb, M Feldmann

    Nature
    |March 1, 1984
    PubMed
    Summary

    Inducing immunological tolerance in T cells requires major histocompatibility complex (MHC) recognition. This process involves antigen recognition and leads to antigen-specific unresponsiveness without cell death.

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    Area of Science:

    • Immunology
    • Cellular Biology

    Background:

    • T-cell responses are typically induced by recognizing antigens presented with major histocompatibility complex (MHC) molecules.
    • The role of MHC recognition in inducing immunological tolerance is not well understood.

    Purpose of the Study:

    • To investigate the requirements for antigen-induced T-cell stimulation and tolerance.
    • To determine if MHC recognition is necessary for the induction of antigen-specific unresponsiveness.

    Main Methods:

    • Used human T helper clones recognizing synthetic influenza haemagglutinin peptides.
    • Employed monoclonal antibodies targeting non-polymorphic regions of human class II MHC antigens to inhibit tolerance induction.

    Main Results:

    • Antigen-specific unresponsiveness (tolerance) was observed in T cells.

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  • Tolerance induction was associated with the loss of T3 antigen from the cell surface.
  • Inhibition of class II MHC antigen recognition prevented tolerance induction.

    • Conclusions:

    • Major histocompatibility complex (MHC) recognition is essential for the induction of T-cell tolerance.
    • Tolerance is not mediated by cell death but involves specific cell surface changes and signaling pathways.