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Acellular bodies in sputum.

B Schmitz, P Pfitzer

    Acta Cytologica
    |March 1, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Acinar bodies in sputum, often concentrically structured and PAS-positive, correlate with inflammation and obstructive lung diseases. Their formation appears rapid and can occur in various locations within the respiratory tract.

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    Area of Science:

    • Pulmonary Medicine
    • Pathology
    • Respiratory System Research

    Background:

    • Acellular bodies in sputum are infrequently observed and their clinical significance remains unclear.
    • Previous studies have not extensively characterized these structures or their associations.

    Purpose of the Study:

    • To characterize the morphology and staining properties of acellular bodies found in sputum.
    • To investigate potential correlations between these bodies and patient demographics, smoking habits, inflammation, and specific pulmonary diseases.

    Main Methods:

    • Analysis of 260 sputum specimens from 70 patients, evaluating acellular bodies for structure, staining (Periodic acid-Schiff), and birefringence.
    • Statistical analysis to determine correlations with clinical parameters including Curschmann spirals, inflammation, sex, smoking, and various cancers and lung diseases.

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    Main Results:

    • Acellular bodies were found in 1% of sputum specimens, typically round to oval, concentrically structured, and often PAS-positive (52% birefringent).
    • A significant correlation was observed between the presence of these bodies and increased Curschmann spirals and inflammation (P < 0.02).
    • Positive correlations were noted with chronic obstructive bronchitis, cor pulmonale, obstructive pulmonary diseases, and lung adenocarcinoma.

    Conclusions:

    • These acellular bodies, potentially originating intra-alveolar, in bronchial glands, or via mucus condensation, are associated with inflammatory lung conditions.
    • Their presence may serve as a biomarker for certain obstructive pulmonary diseases and inflammation.
    • Further research is warranted to elucidate the precise pathogenesis and clinical implications of these structures.