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Related Experiment Videos

Frequency of papillary dysfunction among cholecystectomized patients.

S Bar-Meir, Z Halpern, E Bardan

    Hepatology (Baltimore, Md.)
    |March 1, 1984
    PubMed
    Summary

    Sphincter of Oddi dysfunction, diagnosed via ERCP manometry, may cause abdominal pain in 14% of patients post-gallbladder removal. This condition is rare but can elevate liver enzymes, even without pain.

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    Area of Science:

    • Gastroenterology
    • Hepatology
    • Endocrinology

    Background:

    • Post-cholecystectomy syndrome (PCS) affects patients after gallbladder removal.
    • Upper abdominal pain and abnormal liver enzymes are common PCS symptoms.
    • Sphincter of Oddi dysfunction (SOD) is a potential cause of PCS.

    Purpose of the Study:

    • To investigate the prevalence and diagnostic methods for SOD in patients with PCS.
    • To determine the role of SOD in unexplained abdominal pain and enzyme abnormalities after cholecystectomy.

    Main Methods:

    • Interviewed 454 patients post-gallbladder removal.
    • Assessed for upper abdominal pain and elevated liver enzymes (alkaline phosphatase, amylase).
    • Performed endoscopic retrograde cholangiopancreatography (ERCP) with manometry for diagnosis.

    Main Results:

    • Sphincter of Oddi dysfunction was diagnosed in 14% of patients with PCS.
    • SOD can cause abdominal pain, and rarely, elevated liver enzymes without pain.
    • Papillary dysfunction (a form of SOD) occurred in less than 1% of patients.

    Conclusions:

    • ERCP manometry is a recommended diagnostic tool for PCS.
    • SOD is a significant, though uncommon, cause of persistent symptoms after cholecystectomy.
    • Early diagnosis and management of SOD can improve patient outcomes.

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