Related Experiment Video
Updated: Aug 14, 2026

Cellular Lipid Extraction for Targeted Stable Isotope Dilution Liquid Chromatography-Mass Spectrometry Analysis
Published on: November 17, 2011
Comparative study on the distribution of alpha- and gamma-hexachlorocyclohexane in the rat with particular reference
Abstract:
Blood levels and tissue distributions of alpha-, beta-, gamma- and delta-hexachlorocyclohexane (HCH) were studied following oral administration of alpha-HCH and gamma-HCH to rats. Following administration of alpha-HCH, there was no evidence of beta-HCH, gamma-HCH or delta-HCH, nor could transformation into alpha-HCH, beta-HCH or delta-HCH be detected after exposure to gamma-HCH. After eight weeks of administration, tissue retention of alpha-HCH was 10-20 times greater than that of gamma-HCH. gamma-HCH was eliminated to a much greater extent than alpha-HCH from the tissues, and in particular from fatty tissue. alpha-HCH accumulated in fat and brain, while gamma-HCH showed very low affinity for lipid.
Related Concept Videos
Stability of Substituted Cyclohexanes
The two chair conformations of cyclohexanes undergo rapid interconversion at room temperature. Both forms have identical energies and stabilities, each comprising equal amounts of the equilibrium mixture. Replacing a hydrogen atom with a functional group makes the two conformations energetically non-equivalent.
For example, in...
Disubstituted Cyclohexanes: cis-trans Isomerism
In cyclohexane, the substituents can occupy different positions generating distinct isomers.
Stereoisomerism of Cyclic Compounds
Isomerism in Alkenes
An isomer is called cis-2-butene when the methyl groups are on the same side of the double bond, and the other stereoisomer, in which methyl groups are on the opposite side of the double bond, is called trans-2-butene. The cis and trans stereoisomers are not...
Regioselectivity of Electrophilic Additions to Alkenes: Markovnikov's Rule
The hydrohalogenation of an unsymmetrical alkene can yield two haloalkane products, depending on which vinylic carbon takes up the halogen. However, one product usually predominates, where hydrogen adds to the vinylic carbon bearing the...
Radical Halogenation: Stereochemistry
Halogenation to form a new chiral center:

