Related Experiment Videos
[Fibronectin and other immunologic parameters in chronic polyarthritis]
Zeitschrift Fur Rheumatologie
|January 1, 1984
Summary
Plasma fibronectin levels are normal in rheumatoid arthritis patients and do not indicate disease activity. Other acute phase proteins like C-reactive protein are elevated, suggesting fibronectin is not an acute phase reactant.
Area of Science:
- Rheumatology
- Clinical Chemistry
Context:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation.
- Acute phase proteins are biomarkers used to monitor inflammation and disease activity in RA.
Purpose:
- To investigate plasma fibronectin concentrations in patients with rheumatoid arthritis (RA).
- To correlate fibronectin levels with other established acute phase proteins in RA patients.
- To determine if fibronectin is an acute phase protein and if it provides additional information on RA activity.
Summary:
- Plasma fibronectin concentrations were measured in 20 RA patients and compared to healthy controls.
- RA patients exhibited normal plasma fibronectin levels, unlike elevated C-reactive protein, alpha 1-antitrypsin, alpha 2-antiplasmin, fibrinogen, and C3 complement fraction.
- These findings indicate that fibronectin is not an acute phase protein in the context of RA.
Impact:
- Plasma fibronectin measurement does not offer additional diagnostic value for assessing rheumatoid arthritis activity.
- This study clarifies the role of fibronectin in RA, distinguishing it from other acute phase reactants.