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Related Experiment Videos

[Evaluation of colloidal volume replacement solution 6% HES 40/0.5].

M Halmágyi

    Der Anaesthesist
    |February 1, 1984
    PubMed
    Summary

    This study shows that a 6% hydroxyethyl starch solution effectively expands intravascular volume in hypovolemic volunteers, with minimal impact on blood pressure and a slight increase in glucose. The solution was well-tolerated, with rapid excretion and minimal residual presence.

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    [The feasibility of solutions with adequate fluid exchange in hemofiltration].

    Klinische Anasthesiologie und Intensivtherapie·1993

    Area of Science:

    • Pharmacology
    • Physiology
    • Fluid Resuscitation

    Context:

    • Hypovolemia is a critical condition requiring prompt fluid management.
    • Hydroxyethyl starch (HES) solutions are commonly used for volume expansion.
    • Understanding the pharmacokinetic and hemodynamic effects of HES is crucial for clinical application.

    Purpose:

    • To evaluate the effects of a 6% hydroxyethyl starch 40/0.5 solution on hemodynamic parameters and blood composition in healthy volunteers with induced hypovolemia.
    • To assess the intravascular volume effect, excretion, and residual presence of HES in serum and urine.

    Summary:

    • Infusion of 500 ml of 6% HES in hypovolemic volunteers resulted in significant intravascular volume expansion (71-103% of infused volume).
    • Hemodynamic parameters like blood pressure remained stable, though pulse rate decreased. Minor increases in serum and urine glucose were observed.
    • HES demonstrated rapid excretion, with less than 2% remaining in serum or urine after 240 minutes, indicating efficient clearance and an osmotic diuresis effect.

    Impact:

    • This study provides valuable data on the efficacy and safety profile of 6% HES for managing hypovolemia.
    • Findings support the use of HES as a rapid and effective plasma volume expander.
    • The rapid clearance and minimal residual fraction suggest a favorable pharmacokinetic profile for this HES formulation.

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