A serologic marker for the Ars-C family of anti-arsonate antibodies

Attempts are being made to define, at the serologic, structural and genetic levels, the anti-arsonate repertoire. We previously identified three families of anti-arsonate antibodies based on the amino acid sequence of the heavy chain V regions. The present report establishes the serologic correlates of one of these families, the Ars-C family. The determinants defining this family are expressed by anti-Ar molecules displaying the A/J minor idiotype or the BALB/c major idiotype; these determinants are also expressed on molecules of different specificity, notably by the DNP-binding myelomas, MOPC-460 and MOPC-315. All strains tested employed the Ars-C family in the response to arsonate.