Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histamine.

D L Marquardt

    Clinical Reviews in Allergy
    |September 1, 1983
    PubMed
    Summary
    This summary is machine-generated.

    Histamine mediates allergic reactions via H1 and H2 receptors. Assays measure histamine release and levels, aiding understanding of its role in health and disease.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Dependence of mast cell IgE-mediated cytokine production on nuclear factor-kappaB activity.

    The Journal of allergy and clinical immunology·2000
    Same author

    Mast cell adenosine receptor characteristics and signaling.

    Advances in experimental medicine and biology·1998
    Same author

    Mast cell adenosine induced calcium mobilization via Gi3 and Gq proteins.

    Inflammation·1997
    Same author

    The phosphatidylinositol 3-kinase inhibitor wortmannin blocks mast cell exocytosis but not IL-6 production.

    Journal of immunology (Baltimore, Md. : 1950)·1996
    Same author

    Effects of tubercidin and its 5'-O-methyl ether on adenosine receptors and mediator release functions in mast cells.

    Journal of medicinal chemistry·1995
    Same author

    Inhibition of protein kinase A fails to alter mast cell adenosine responsiveness.

    Agents and actions·1994

    Area of Science:

    • Immunology
    • Pharmacology
    • Biochemistry

    Background:

    • Histamine is a key mediator of immediate hypersensitivity.
    • It acts via H1 and H2 cell surface receptors.
    • Histamine influences vascular permeability, immune cell activity, and smooth muscle contraction.

    Purpose of the Study:

    • To review the role of histamine in hypersensitivity reactions.
    • To discuss the mechanisms of H1 and H2 antihistamines.
    • To summarize biochemical assays for histamine assessment.

    Main Methods:

    • Review of existing literature on histamine.
    • Description of pharmacological actions of histamine.
    • Overview of biochemical and bioassay techniques.

    Related Experiment Videos

    Main Results:

    • Histamine release from mast cells and basophils triggers allergic responses.
    • H1 and H2 antihistamines are effective in treating conditions like urticaria and rhinoconjunctivitis.
    • Various assays, including bioassays and biochemical methods, quantify histamine levels.

    Conclusions:

    • Histamine is a critical mediator in allergic and inflammatory processes.
    • Antihistamines targeting H1 and H2 receptors offer therapeutic benefits.
    • Accurate measurement of histamine is essential for research and clinical applications.