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Related Experiment Videos

Somatomedin carrier proteins.

G L Smith

    Molecular and Cellular Endocrinology
    |February 1, 1984
    PubMed
    Summary

    Growth hormone mediators, somatomedins (like insulin-like growth factors), circulate in serum as large complexes. These complexes act as reservoirs, regulating hormone delivery to target cells.

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    Area of Science:

    • Endocrinology
    • Molecular Biology
    • Protein Chemistry

    Background:

    • Somatomedins, including insulin-like growth factors (IGFs) I and II, are growth hormone-dependent polypeptides.
    • They are believed to mediate growth hormone's effects on extraskeletal tissues.
    • Unlike most hormones, somatomedins circulate in serum as high molecular weight complexes (approx. 150,000 and 60,000 Da).

    Purpose of the Study:

    • To investigate the subunit composition of somatomedin serum carrier protein complexes.
    • To understand how these complexes affect the biological activity of somatomedins.
    • To elucidate the physiological control system for somatomedin delivery.

    Main Methods:

    • Analysis of serum carrier protein complexes.
    • Investigation of somatomedin subunit composition.
    • Studies on the biological activity of somatomedins within complexes.

    Main Results:

    • Somatomedins exist in serum primarily within two distinct high molecular weight complexes.
    • Little free somatomedin is detectable in plasma.
    • These complexes serve as a reservoir, with circulating concentrations far exceeding free hormone levels.

    Conclusions:

    • The circulating somatomedin-IGF complexes are crucial reservoirs for these hormones.
    • An intricate physiological system regulates these complexes.
    • This system ensures the targeted delivery of somatomedins to specific cell receptors.

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