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Related Experiment Videos

Pathogenetic difference between collagen arthritis and adjuvant arthritis.

N Kaibara, T Hotokebuchi, K Takagishi

    The Journal of Experimental Medicine
    |May 1, 1984
    PubMed
    Summary

    Cyclosporin treatment suppressed collagen and adjuvant arthritis in rats. This immunosuppression was antigen-specific, indicating that cyclosporin can induce targeted immune tolerance for arthritis treatment.

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    Area of Science:

    • Immunology
    • Rheumatology
    • Pharmacology

    Background:

    • Cyclosporin is an immunosuppressive drug.
    • Collagen arthritis and adjuvant arthritis are animal models of polyarthritis.

    Purpose of the Study:

    • To determine if cyclosporin-induced immunologic unresponsiveness is antigen-specific.
    • To investigate the role of type II collagen immunity in collagen and adjuvant arthritis pathogenesis.

    Main Methods:

    • Rats were treated daily with cyclosporin (25 mg/kg) for 14 days.
    • Protected rats were rechallenged with type II collagen or complete Freund's adjuvant (CFA) after cyclosporin withdrawal.
    • Arthritis development was observed over 45 days.

    Main Results:

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  • Cyclosporin completely suppressed collagen and adjuvant arthritis development.
  • Rechallengetests demonstrated antigen-specific unresponsiveness to type II collagen and CFA.
  • Immunity to type II collagen is critical for collagen arthritis but not adjuvant arthritis.

    • Conclusions:

    • Cyclosporin induces antigen-specific immunologic unresponsiveness in experimental polyarthritis models.
    • There is no cross-reactivity between type II collagen and mycobacterial components.
    • Type II collagen immunity is a key factor in collagen arthritis pathogenesis.