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Related Experiment Videos

Progesterone receptors in the prostate.

J A Belis, E F Lizza, W F Tarry

    Progress in Clinical and Biological Research
    |January 1, 1984
    PubMed
    Summary

    Estradiol boosts progesterone binding in rat prostates. Combined progesterone and estradiol treatments selectively stimulate lateral prostate growth, indicating a role for the progesterone receptor in this response.

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    Area of Science:

    • Endocrinology
    • Urology
    • Molecular Biology

    Background:

    • The prostate gland's growth and function are influenced by steroid hormones.
    • Progesterone's role in prostate tissue, particularly in castrate models, is not fully understood.
    • Specific cytosol progesterone binding sites exist in the lateral prostate but are low in castrate rats.

    Purpose of the Study:

    • To investigate the effect of estradiol on progesterone binding in the rat prostate.
    • To determine the role of progesterone and estradiol in stimulating prostate growth.
    • To explore the mechanism of progesterone action in the lateral prostate.

    Main Methods:

    • Castrate rats were treated with estradiol, progesterone, or a combination of both.
    • Specific cytosol progesterone binding was measured in the lateral and ventral prostate.
    • Prostate growth was assessed following hormonal treatments.

    Main Results:

    • Estradiol treatment increased specific cytosol progesterone binding in the lateral prostate.
    • Combined progesterone and estradiol administration led to selective growth of the lateral prostate.
    • The ventral prostate showed minimal progesterone binding and did not respond to estradiol or combined treatments.

    Conclusions:

    • The cytosol progesterone receptor in the lateral prostate can mediate a growth response to an agonist.
    • Progesterone's effects in the lateral prostate are not mediated through the androgen receptor.
    • The endogenous agonist for the prostate cytosol progesterone receptor and its relevance to benign prostatic hyperplasia (BPH) require further investigation.

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