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[Polypeptides and antagonists].

D Regoli

    La Semaine Des Hopitaux : Organe Fonde Par L'Association D'Enseignement Medical Des Hopitaux De Paris
    |March 29, 1984
    PubMed
    Summary
    This summary is machine-generated.

    Polypeptides regulate physiology and disease. Antagonists offer therapeutic potential by targeting systems like the renin-angiotensin system, crucial for blood pressure control and hypertension management.

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    Area of Science:

    • Biochemistry and Physiology
    • Pharmacology
    • Endocrinology

    Context:

    • Polypeptides are endogenous signaling molecules with diverse physiological roles.
    • Dysregulation of polypeptide systems contributes to various diseases, including hypertension.
    • Polypeptide antagonists represent a promising class of therapeutic agents.

    Purpose:

    • To review the physiological functions of key polypeptides.
    • To explore the role of polypeptide systems in disease pathogenesis, particularly arterial hypertension.
    • To discuss the therapeutic potential of polypeptide antagonists.

    Summary:

    • Polypeptides like angiotensin and kinins act as hormones or autacoids, while others like substance P and neurotensin function as neurotransmitters.
    • The renin-angiotensin system regulates blood pressure; its overactivity is a cause of hypertension, manageable by blocking renin secretion, angiotensin conversion, or receptor action.

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  • Bradykinin mediates inflammation, substance P transmits pain and causes vasodilation, neurotensin induces hypothermia and analgesia, and vasoactive intestinal peptide affects gastric and intestinal functions.

    • Impact:

    • Understanding polypeptide functions and dysregulation is key to developing novel treatments for hypertension and inflammatory conditions.
    • Targeting specific polypeptide pathways offers new therapeutic strategies for cardiovascular and neurological disorders.
    • This review highlights the broad impact of polypeptides in physiological regulation and disease, emphasizing the therapeutic promise of their antagonists.