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Adrenocortical suppression in workers manufacturing synthetic glucocorticoids
British Medical Journal
|January 14, 1978
Summary
Workers manufacturing potent corticosteroids may develop adrenal insufficiency due to chronic absorption. Regular screening of plasma cortisol and job rotation are recommended to prevent this occupational hazard.
Area of Science:
- Occupational Health
- Endocrinology
- Pharmacology
Background:
- Corticosteroid manufacturing poses potential health risks to workers.
- Chronic exposure to potent glucocorticoids can lead to adrenal suppression.
Observation:
- A worker manufacturing a potent corticosteroid developed chronic adrenocortical insufficiency.
- Facial plethora was observed in all 12 workers, indicating drug absorption despite safety measures.
Findings:
- Two of eleven screened workers, including one with only seven months of employment, showed abnormal responses to the Synacthen (tetracosactrin) test.
- Chronic absorption of glucocorticoids can cause adrenocortical insufficiency in manufacturing workers.
Implications:
- Regular screening of plasma cortisol levels is crucial for workers in potent steroid manufacturing.
- Job rotation to non-steroid processing areas should be implemented to minimize exposure risks.