A probe of the human plasmin-alpha 2-macroglobulin interaction utilizing monoclonal antibodies to human plasmin

These experiments have shown that alpha 2M may have a bait region capable of accommodating proteases of a far greater molecular weight than previously recognized, since antibody-plasmin complexes apparently become entrapped. In the case of large proteases, however, it now appears that a portion of these molecules is not enclosed. Clearly, in the case of plasmin, the K1-4 region remains outside the molecular trap.