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Related Experiment Videos

Hydroxyethylstarch administration does not depress reticuloendothelial function or increase mortality from sepsis.

C H Shatney, I H Chaudry

    Circulatory Shock
    |January 1, 1984
    PubMed
    Summary

    Hydroxyethylstarch (HES) did not impair the reticuloendothelial system (RES) or host resistance to sepsis in rats. This study found no adverse effects of HES on immune function or survival rates during infection.

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    Area of Science:

    • Critical care medicine
    • Immunology
    • Pharmacology

    Background:

    • Hydroxyethylstarch (HES) is increasingly used for hemorrhagic shock.
    • Concerns exist regarding HES's impact on the reticuloendothelial system (RES) and sepsis defense.

    Purpose of the Study:

    • To evaluate the effects of HES on RES function.
    • To assess HES's influence on host resistance to sepsis.

    Main Methods:

    • Male albino Holtzman rats received HES or saline (60 ml/kg) intravenously.
    • RES function was measured by 131I-triolein lipid emulsion clearance and organ retention.
    • Sepsis was induced via cecal ligation and puncture 2 days post-infusion.

    Main Results:

    • HES did not affect intravascular clearance rates or organ retention of lipid emulsion at 24 or 48 hours.

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  • Survival rates in HES-treated rats (43%) were similar to saline controls (41%) after sepsis induction.

    • Conclusions:

    • Clinically relevant volumes of HES do not appear to impair RES function.
    • HES administration does not compromise host resistance to sepsis in this rat model.