[Combined use of interferon inducers and recombinant influenza viruses for protection from the disease]

The data on the use of national interferon inducers ( polyguacyl and double-stranded RNA) in combination with original H1N1 and H3N2 influenza viruses and recombinant strains with the same antigenic properties in laboratory animals are presented. Recombinants were found to produce a more marked effect: 3--6-fold increased protection of mice depending on the interferon inducer, higher titres of interferon and antibody, than the original influenza viruses. A simultaneous use of interferon inducers and recombinant influenza virus strains may be recommended for influenza prevention.