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Lichen amyloidosus. Ultrastructure and pathogenesis.

J Jambrosic, L From, W Hanna

    The American Journal of Dermatopathology
    |April 1, 1984
    PubMed
    Summary
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    Lichen amyloidosus amyloid fibrils originate from epidermal keratinocytes undergoing apoptosis. These cells transform into Civatte bodies, which deposit in the dermis, where they mature into amyloid.

    Area of Science:

    • Dermatopathology
    • Cell Biology
    • Biochemistry

    Background:

    • Lichen amyloidosus is a skin condition characterized by amyloid deposition.
    • The precise origin and formation process of amyloid fibrils in this condition remain incompletely understood.

    Purpose of the Study:

    • To investigate the ultrastructural basis of amyloid formation in lichen amyloidosus.
    • To elucidate the role of epidermal keratinocytes and tonofilaments in amyloid fibrilogenesis.

    Main Methods:

    • Ultrastructural analysis of skin biopsies from six patients with lichen amyloidosus.
    • Transmission electron microscopy was employed to examine cellular and extracellular components.

    Main Results:

    • Keratinocytes undergo apoptosis, transforming into filamentous cells and then Civatte bodies.

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  • These Civatte bodies migrate into the papillary dermis, associating with amyloid deposits.
  • Amyloid fibril formation, characterized by straight, nonbranching filaments, was observed in the dermis, potentially facilitated by dermal fibroblasts.

    • Conclusions:

    • Epidermal keratinocytes, via apoptosis and transformation into Civatte bodies, serve as precursors for amyloid fibrils in lichen amyloidosus.
    • The final conversion to characteristic amyloid fibrils occurs in the dermis, possibly with the assistance of dermal fibroblasts.