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Updated: Aug 19, 2026

5/6th Nephrectomy in Combination with High Salt Diet and Nitric Oxide Synthase Inhibition to Induce Chronic Kidney Disease in the Lewis Rat
Published on: July 3, 2013
Exchangeable sodium in renal hypertension in the rat
Abstract:
Rats with two-kidney, one-clip hypertension (2K1C) have a marked rise in plasma renin activity (PRA) and, when drinking 0.9% NaCl as their sole source of sodium, have increased exchangeable and total body sodium levels. These changes are reversed by the administration of captopril. The one-kidney, one-clip (1K1C) model has no rise in PRA or increase in body sodium level after either an early or a late contralateral nephrectomy. The data indicate that hypertension in the 2K1C model is due to the high angiotensin levels in these animals. Activation of the renin-angiotensin system requires the presence of the contralateral kidney but is not the result of sodium loss from that kidney. The reason for activation of the renin-angiotensin system in the 2K1C hypertensive rat remains obscure.
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