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Tetraparental rabbits chimeric for their lymphoid system--II. Idiotype expression

G R Bordenave, C Babinet

    Molecular Immunology
    |May 1, 1984
    PubMed

    In order to test some aspects of the network theory of "idiotype-anti-idiotype" interactions, we studied the idiotypic specificities of anti-DNP antibodies produced by tetraparental rabbits, chimeric for their lymphoid system, under two different experimental conditions. In the first, the tetraparental rabbits were simply immunized against the hapten and we observed that the antibodies, totally different in their allotypy, produced by the lymphocytes of the two constitutive parental strains remained idiotypically independent in three cases out of three. In the second experimental regimen, the tetraparental rabbits underwent an anti-anti-idiotypic immunization before the anti-hapten one. In two out of the four cases studied we observed that anti-DNP antibodies different in their a- and b-series allotypic specificities can bear at least related idiotypic specificities.

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