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Spontaneous degenerative maculopathy in the monkey
Ophthalmology
|May 1, 1984
Summary
Diurnal primates, particularly rhesus monkeys, exhibit maculopathy-related changes like drusen-like bodies and lesions associated with myopia. These findings offer insights into conditions observed in clinical practice.
Area of Science:
- Ophthalmology
- Primate Ophthalmology
- Comparative Pathology
Background:
- Maculopathy presents with diverse clinical manifestations.
- Subhuman diurnal primates can exhibit ocular changes relevant to human conditions.
Purpose of the Study:
- To investigate the presence and characteristics of maculopathy-related lesions in a cohort of diurnal subhuman primates.
- To correlate observed primate ocular findings with those seen in human clinical practice.
Main Methods:
- Ophthalmoscopic examination of 574 diurnal subhuman primates, predominantly older rhesus monkeys.
- Documentation and analysis of observed lesions in the macula and other fundus regions.
Main Results:
- 5.9% of subjects presented with drusen-like bodies in the macula and fundus.
- Choroidal rupture-like crescent-shaped lesions were identified.
- Macular and perimacular lesions associated with myopia, some complicated by choroidal neovascularization, were observed.
Conclusions:
- Diurnal primates, specifically rhesus monkeys, display ocular pathologies mirroring aspects of human maculopathy.
- These findings contribute to understanding the comparative pathology of retinal diseases.