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Related Experiment Videos

Lanthionine detected in human urine.

S K Wadman, P K De Bree, J P Kamerling

    Clinica Chimica Acta; International Journal of Clinical Chemistry
    |January 16, 1978
    PubMed
    Summary

    Lanthionine, an unusual amino acid, was found in patient urine, potentially linked to a Yersinia infection. This finding suggests gut bacteria may produce lanthionine, rather than it being endogenous.

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    Area of Science:

    • Biochemistry
    • Microbiology
    • Clinical Chemistry

    Background:

    • Lanthionine is a non-proteinogenic amino acid.
    • Abnormal amino acid detection in urine can indicate metabolic or infectious processes.

    Purpose of the Study:

    • To identify an incidentally detected amino acid in patient urine.
    • To investigate the potential origin of the detected amino acid.

    Main Methods:

    • Gas chromatography-mass spectrometry (GC-MS) analysis of the N-trifluoroacetyl methyl ester derivative of the amino acid.
    • Clinical case observation.

    Main Results:

    • Lanthionine (L-, D-, and meso-forms) was detected in the urine of a patient with an abdominal pseudo-tumor.
    • The presence of lanthionine was confirmed using GC-MS.
    • The amino acid was suspected to be of exogenous origin, possibly from gut bacteria.

    Conclusions:

    • The detection of lanthionine in urine may be associated with Yersinia infections.
    • Gut bacteria are a potential source of lanthionine in humans.
    • Further investigation into bacterial amino acid production in clinical settings is warranted.

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