Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Histiocytic malignancies. Morphologic, immunologic, and enzymatic heterogeneity.

R R Turner, G S Wood, J H Beckstead

    The American Journal of Surgical Pathology
    |July 1, 1984
    PubMed
    Summary

    This study analyzed 14 hematopoietic malignancies, revealing diverse histiocytic differentiation using immunologic and enzymatic techniques. These methods help classify these complex blood cancers.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Topical application of delphinidin reduces psoriasiform lesions in the flaky skin mouse model by inducing epidermal differentiation and inhibiting inflammation.

    The British journal of dermatology·2014
    Same author

    Prognostic factors, prognostic indices and staging in mycosis fungoides and Sézary syndrome: where are we now?

    The British journal of dermatology·2014
    Same author

    Polo-like kinase 1 (Plk1) in cutaneous T-cell lymphoma.

    The British journal of dermatology·2010
    Same author

    Light-chain-restricted germinal centres in reactive lymphadenitis: report of eight cases.

    Histopathology·2008
    Same author

    Genomic instability in radial growth phase melanoma cell lines after ultraviolet irradiation.

    Journal of clinical pathology·2005
    Same author

    p53-related pathways and the molecular pathogenesis of melanoma.

    European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP)·2003

    Area of Science:

    • Hematology
    • Oncology
    • Immunohistochemistry

    Background:

    • Histiocytic malignancies present diagnostic challenges due to their heterogeneity.
    • Accurate subclassification is crucial for appropriate patient management and treatment strategies.

    Purpose of the Study:

    • To investigate the morphologic, immunologic, and enzymatic characteristics of 14 hematopoietic malignancies with features of histiocytic differentiation.
    • To explore the utility of immunologic stains and enzyme histochemistry in subtyping these neoplasms.

    Main Methods:

    • Utilized frozen section immunologic stains, plastic section enzyme histochemistry, and paraffin section immunocytochemistry.
    • Analyzed 14 cases of hematopoietic malignancies exhibiting histiocytic differentiation.

    Related Experiment Videos

    Main Results:

    • Observed significant heterogeneity in morphologic, immunologic, and enzymatic profiles.
    • Identified distinct subsets suggesting differentiation towards monocyte/macrophage, interdigitating reticulum cells, and fibroblastic reticulum cells.
    • Four cases were poorly differentiated, and three were reclassified as T-cell lymphomas.

    Conclusions:

    • Histiocytic malignancies represent a diverse group of neoplasms.
    • Immunologic and enzymatic techniques are essential for identifying and subclassifying these challenging hematologic cancers.