Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone blood flow and age in the rat.

J N MacPherson, P Tothill

    Clinical Science and Molecular Medicine
    |January 1, 1978
    PubMed
    Summary

    Skeletal blood flow decreases in rats as they age, affecting specific bones like the femur but not the ribs or skull. Overall skeletal blood flow remains about 3% of cardiac output.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Re: "DXA in vivo BMD methodology: an erroneous and misleading research and clinical gauge of bone mineral status, bone fragility, and bone remodelling" by H.H. Bolotin (Bone 2007; 41:138-154).

    Bone·2007
    Same author

    Precision and accuracy of measuring changes in bone mineral density by dual-energy X-ray absorptiometry.

    Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2007
    Same author

    Dual-energy X-ray absorptiometry measurements of fat and lean masses in subjects with eating disorders.

    International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity·2004
    Same author

    Bone mineral and soft tissue measurements by dual-energy X-ray absorptiometry during growth.

    Bone·2002
    Same author

    Allelic association discriminates draft orders.

    Annals of human genetics·2002
    Same author

    Comparisons between a pencil beam and two fan beam dual energy X-ray absorptiometers used for measuring total body bone and soft tissue.

    The British journal of radiology·2001

    Area of Science:

    • Physiology
    • Biomedical Engineering

    Background:

    • Understanding skeletal blood flow is crucial for bone health and development.
    • Previous estimates of skeletal blood flow vary, necessitating precise measurement techniques.

    Purpose of the Study:

    • To quantify the proportion of cardiac output delivered to the entire skeleton and individual bones in rats.
    • To investigate the relationship between age, weight, and skeletal blood flow distribution.

    Main Methods:

    • Radioactive microspheres were used to measure blood flow in rats of varying ages and weights.
    • Cardiac output was assessed to determine the percentage delivered to skeletal tissues.

    Main Results:

    • Blood flow to specific bones (tibia-fibula, jaw, femur, pelvis, humerus, radius/ulna, scapula) decreased with increasing age and weight.
    • Blood flow to the ribs, spine, and skull showed no significant change with age or weight.
    • The whole skeleton received approximately 3% of the cardiac output.

    Conclusions:

    • Skeletal blood flow distribution is influenced by age and body weight in rats.
    • Specific long bones and the jaw show reduced blood flow with aging, while axial and cranial bones remain relatively constant.
    • These findings align with previous estimates using 45Ca clearance methods.

    Related Experiment Videos