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Does simian virus 5 infect humans?

K K Goswami, L S Lange, D N Mitchell

    The Journal of General Virology
    |August 1, 1984
    PubMed
    Summary
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    Simian virus 5 (SV5) can infect humans, as evidenced by neutralizing antibodies found in human sera. However, current tests do not indicate a causal link between SV5 infection and multiple sclerosis (MS).

    Area of Science:

    • Virology
    • Immunology
    • Neurology

    Background:

    • Simian virus 5 (SV5) is a paramyxovirus.
    • Multiple sclerosis (MS) is a chronic neurological disease.
    • The potential role of viral infections in MS etiology is an area of ongoing research.

    Purpose of the Study:

    • To investigate the presence of SV5 in human samples.
    • To determine if SV5 infection is associated with multiple sclerosis.

    Main Methods:

    • Co-cultivation of human bone marrow aspirates with SV5.
    • Immunoprecipitation, cross-neutralization, and haemagglutination inhibition assays.
    • Analysis of human sera for neutralizing antibodies and epitope blocking.

    Main Results:

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    • SV5 isolates from MS patients were antigenically similar to the prototype strain.
    • Approximately 20% of human sera (MS and control) contained SV5-neutralizing antibodies.
    • Human sera with neutralizing activity blocked specific SV5 epitopes, confirming human infection.

    Conclusions:

    • SV5 infection in humans is suggested by the presence of neutralizing antibodies.
    • No etiological relationship between SV5 infection and the induction of MS was indicated by these findings.