Related Experiment Video

Updated: Sep 30, 2026

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice
10:23

Urinary Tract Infection in a Small Animal Model: Transurethral Catheterization of Male and Female Mice

Published on: December 1, 2017

Morphologic and immunohistologic study of pyelonephritis in rats by various bacteria and fungi. Special reference to

T Nagai

    Nephron
    |January 1, 1984
    PubMed

    Insights

    This study investigated experimental pyelonephritis in rats using various pathogens. Findings show persistent antigens can lead to scarring, even after clearance, with Candida pyelonephritis showing high incidence of renal sclerosis.

    Area of Science:

    • Nephrology
    • Pathology
    • Immunology

    Background:

    • Pyelonephritis, a kidney infection, can lead to significant renal damage.
    • Understanding the pathological and immunological responses to different pathogens is crucial for treatment strategies.

    Purpose of the Study:

    • To investigate the pathological and immunohistological changes in experimental pyelonephritis induced by Pseudomonas aeruginosa, Serratia marcescens, Candida albicans, and Cryptococcus neoformans in rats.
    • To determine the persistence of bacterial and fungal antigens in renal lesions and their correlation with inflammation and scarring.

    Main Methods:

    • Induction of experimental pyelonephritis in rats via intrarenal injection of pathogens.
    • Pathological examination of renal tissues.
    • Immunohistological analysis for localization of bacteria, fungi, antigens, and rat gamma globulin.

    Main Results:

    • Induced lesions mimicked human pyelonephritis.
    • Bacterial antigens persisted for 10-12 weeks, fungal antigens for 6-8 weeks.
    • Progressive scarring occurred even without persistent antigens; rat gamma globulin localized in plasma cells.
    • Candida albicans induced a high incidence of progressive renal sclerosis.

    Conclusions:

    • Persistent inflammation and scarring can occur in pyelonephritis independently of ongoing antigen presence.
    • Candida albicans may play a significant role in progressive renal scarring in pyelonephritis.

    More Related Videos

    Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis06:09

    Intrarenal Injection of Escherichia coli in a Rat Model of Pyelonephritis

    Published on: July 18, 2017

    Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns08:30

    Mouse Models of Epididymitis Induced by Pathogen-Associated Molecular Patterns

    Published on: December 12, 2025

    Related Concept Videos

    Acute Pyelonephritis I: Introduction01:27

    Acute Pyelonephritis I: Introduction

    Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such as Proteus,...
    Acute Pyelonephritis II: Diagnostic Studies and Management01:28

    Acute Pyelonephritis II: Diagnostic Studies and Management

    Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...