Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mechanisms of maculopathy.

R C Eagle

    Ophthalmology
    |June 1, 1984
    PubMed
    Summary

    This review explores how cellular changes in the macula contribute to macular diseases like senile macular degeneration and diabetic retinopathy. Understanding these cellular processes is key to developing treatments for vision loss.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The pathology of ocular cancer.

    Eye (London, England)·2012
    Same author

    Association of a nonsynonymous single-nucleotide polymorphism of matrix metalloproteinase 9 with giant cell arteritis.

    Arthritis and rheumatism·2008
    Same author

    Significant head cooling can be achieved while maintaining normothermia in the newborn piglet.

    Archives of disease in childhood. Fetal and neonatal edition·2005
    Same author

    Bilateral microphthalmos and orbital cyst.

    Eye (London, England)·2003
    Same author

    The equine hypophysis: a gland for all seasons.

    Reproduction, fertility, and development·2002
    Same author

    Clinicopathologic reports, case reports, and small case series: progressive growth of benign adenoma of the pigment epithelium of the ciliary body.

    Archives of ophthalmology (Chicago, Ill. : 1960)·2001

    Area of Science:

    • Ophthalmology
    • Cell Biology
    • Pathogenesis of Macular Diseases

    Background:

    • The macula's cellular constituents play a crucial role in various macular diseases.
    • Retinal pigment epithelium (RPE) dysfunction is implicated in senile macular degeneration (SMD).
    • Environmental factors and inherited conditions can increase RPE susceptibility.

    Purpose of the Study:

    • To review the cellular components of the macula.
    • To speculate on their contribution to macular disease pathogenesis.
    • To discuss cellular mechanisms in SMD, macular edema, and diabetic retinopathy.

    Main Methods:

    • Literature review of cellular constituents in macular diseases.
    • Analysis of RPE, Müller cell, and vascular roles.
    • Discussion of inflammatory mediators and angiogenic factors.

    Main Results:

    • RPE dysfunction from cumulative damage contributes to SMD.
    • Excessive extracellular matrix production by RPE can lead to neovascularization.
    • Müller cell dysfunction and vascular issues are key in macular edema and diabetic retinopathy.

    Conclusions:

    • Cellular dysfunction and damage are central to macular disease development.
    • Understanding these cellular processes is vital for therapeutic strategies.
    • The macula's unique physiology makes it susceptible to various pathological conditions.

    Related Experiment Videos